One of the often given fixed-dose combination medications
with two active ingredients—clopidogrel and aspirin products—is Ogrel Plus 81.
Due to its strong antiplatelet efficacy, this combination medication is
frequently recommended to treat cardiovascular diseases and thrombotic events
like as myocardial infarction (MI) and stroke. It also helps to prevent or
lessen the risk of other major thrombotic events. In-depth discussion of Ogrel
Plus 81's usage, dosage, and necessary side effect precautions is provided in
this page.
Introduction of Ogrel Plus 81
Ogrel Plus 81 is a combination drug with Clopidogrel and
Aspirin as ingredients. It is classified among antiplatelet agents whose
activity is based on the cumulative or enhancing effect principle, preventing
the formation of blood clots considered dangerous or fatal. In most cases, this
medication is prescribed to at-risk cardiovascular event patients for proven
efficacy in reducing their chances of a heart attack, stroke, and other similar
occurrences.
Indications of Ogrel Plus 81
Ogrel Plus 81 is primarily indicated to help decrease the
occurrence of thrombotic events in patients with the following conditions:
- Recent Myocardial Infarction (MI): Ogrel Plus 81 reduces the
rate of new ischemic stroke, MI, and other vascular deaths in patients with
recent MI.
- Recent Stroke: It reduces the probability of repeated
strokes in people experiencing previous episodes of ischemic stroke.
Ogrel Plus 81 is also related to the treatment and
management of a number of other conditions, which include,
- Cardiovascular disease (CVD)
- Colorectal adenomas and cancers
- Headache and migraine
- Rheumatoid arthritis and other inflammatory conditions
- Pain management in cases of common cold and flu and
menstrual pain
Mechanism of Action of Ogrel Plus 81
Clopidogrel:
The antiplatelet medication Plavix contains clopidogrel. The
medication prevents ADP from attaching to its platelet receptor by acting as a
particular and selective inhibitor. Consequently, it prevents the stimulation
(activation) of the glycoprotein GpIIb/IIIa complex. Clopidogrel's irreversible
inhibitory impact further reduces the likelihood of clot formation.
Aspirin:
Aspirin goes through irreversible inhibition of the cyclooxygenase
(COX) enzyme that leads to the antiplatelet effect. This reduces the occurrence
of clot-inducing cardiovascular events since the formed platelets actively
participate in thromboxane A2 creation – a very potent agent in platelet
aggregation.
Efficacy:
This combination of two agents, aspirin and ticlopidine,
offers dual action. This makes Ogrel Plus 81 a significantly potent drug in the
prevention of thrombotic events.
Dosage Guidelines
The dosage of Ogrel Plus 81 will be dependent on the condition
being treated:
For Recent MI, Stroke, or Established PAD: One tablet taken
once a day is the common dosage.
Acute Coronary Syndrome—Treatment is initiated within four
tablets as a loading dose and continued with one tablet daily.
Pediatric Use: Ogrel Plus 81 has not been proven safe or
effective in the pediatric population, so its use should be avoided in
children.
Adverse Effects of Ogrel Plus 81
Ogrel Plus 81 is tolerable; however, the side effects as of now are unknown to many patients although few patients have reported. The commonly reported side effects are as follows:
- GI Distress: Abdominal pain and cramps, dyspepsia,
gastritis, diarrhea, bloating, and nausea/vomiting, and constipation.
- Hematological: Gastrointestinal hemorrhage with ulcers, neutropenia.
- Neurological Effects: Musculoskeletal: only sleep
disturbances, neuralgia par aesthesia and dizziness were reported.
This medicine has being reported to cause G. I. haemorrhage,
TTP and anaphylactic reactions as serious but uncommon side effects. These are
conditions that may be rare, and therefore in the event that they are realized,
seek the assistance of your doctor as
Bleeding:
Hence, since Ogrel plus 81 comes under the antiplatelet
category, there is a increased likelihood of bleeding. Regarding the
contraindication, the doctor should be more cautious while managing patients
who have undergone surgery within the last 90 days or those that involved in a
major trauma within the two months preceding the study or those patients with a
bleeding tendency.
Reye's Syndrome:
It is necessary to notice that the major active component of
this composition of Ogrel Plus 81 seems to be aspirin. The patients are more
prone to viral ailments and the youths and adolescence young chaps in their
productive prime of youth are the most vulnerable to Reye’s syndrome.
Hepatic and Renal Impairments:
Concerning the contraindicated symptoms, aspirin is likely
to worsen the symptoms in patients with liver and kidney ailments.
Drug-Drug Interactions
Thus, when Ogrel Plus 81 is combined with other medications, the effect of the interacting medication could be reduced or the risk could be increased. The following are the main interactions that this medication has:
- Anticoagulants and Other Antiplatelet Agents: When both
agents are used, the tendency to have bleeding is much higher.
- Non-steroidal anti-inflammatory drugs (NSAIDs): All these
medications add on to the effectiveness of the Ogrel Plus 81 in.
- Antihypertensive Medication: Corticosteroids and aspirin
were identified to counteract the effects of drugs used in management of
hypertension.
Pregnancy and Lactation
- Pregnancy: That is why due to the high risk of emergence of
maternal hemorrhage Ogrel Plus 81 is prescribed during pregnancy only in cases
when the expected benefit of its utilize exceeds the potential harm to the
fetus and its administration is impossible in the third trimester.
- Breastfeeding: Aspirin can be dangerous to the developing
child during its excretion in breast milk and thus Ogrel Plus 81 is advised not
to be taken by nursing mothers.
Overdosage and Hazardous Materials
As for the overdosing on Ogrel Plus 81 which is
controversial to be taken, a patient is likely to die fatally due to the
presence of aspirin in the medication. Call for professional medical assistance
is required, and adjuvant measures like gastric lavage, activated charcoal and
supporting management can be done.
Guidelines for Storage
It is advised to keep Ogrel Plus 81 at room temperature
absorbing humidity and light as much as possible. Ensure that the medication is
not within the reach of pets and children.
Conclusion
Though potent in composition, Ogrel Plus 81, the combination
form, has been a significant medication in preventing thrombotic events among
high-risk patients. Though this drug has significant benefits, it is wise to
use it under the care of a healthcare provider because of the potential side
effects and drug interactions. In most cases, understanding indications,
dosage, precautions, and other related information about Ogrel Plus 81 will
enable patients to make informed decisions, thus offering them maximum benefits
while reducing risks.
Please book an appointment with the best Cardiologist in Lahore, Karachi, Islamabad, and all major cities of Pakistan through InstaCare, or call our helpline at 03171777509 to find the verified doctor for your disease.
