Viglip-M 50/1000 mg is a unique medicinal product with proven efficacy for diabetes mellitus type 2. It comprises two highly potent actives: vildagliptin and metformin hydrochloride. Each added component gives other potencies, which differ in controlling sugar in the blood, hence making the drug so useful in treating this disease. Therefore, the mechanisms, benefits, possible side effects, precautions, and practical application should be understood very well by the patients and even the healthcare providers.
Active Ingredients Regarding Viglip-M (50/1000mg)
1. Vildagliptin
Mechanism of Action
Vildagliptin is a DPPIV chemical inhibitor analog. The drug works through the inhibition of DPP-IV, which would work in the degradation of the incretin hormones, GLP-1, and GIP. These hormones would thus have their action prolonged. As a result, the glucose-dependent stimulatory action of GLP-1 and GIP on insulin secretion works to reduce blood glucose concentrations in the postprandial state.
Benefits
Stimulated higher insulin secretions by using vildagliptin; enhanced pancreatic islet function; the consequence of these beneficial effects, the vildagliptin has in the maintenance of glycemic control in type 2 diabetes mellitus. It is a single agent or is used adjunctively with some other antidiabetic medicine and permits flexible treatment options.
2. Metformin Hydrochloride
Mechanism of action
Metformin is the most commonly used drug for type 2 diabetes treatment. Its pharmacological activities are in the reduction of hepatic glucose output and an increased insulin sensitivity in peripheral tissues, basically cellular uptake of glucose. Other mechanisms for metformin include reduced intestinal absorption of glucose, which is an additive action leading to reduced fasting and postprandial blood glucose concentrations.
Benefits
The significant advantage of metformin is a very marked reduction in HbA1c, driven improvements in insulin sensitivity, and reduced diabetes-associated cardiovascular complications. Consequently, it was utilized as the initial therapy line because of its safety profile and effectiveness in the management of hyperglycemia.
Indications
Viplig-M 50 mg/1000 mg is indicated for the treatment of type 2 diabetes mellitus after 18 years of age, but it is indicated only in patients with inadequate glycemic control despite a combination of diet and exercise and monotherapy with either vildagliptin or met formative. Vigrilg M is a combination of two drugs that act through mechanisms correlating to glucose metabolism, but in different ways, hence bringing a synergistic action over blood sugar control.
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Administration
Viglip-M is administered at a dose of 50/1000 mg. Still, these are altered depending on the response to the drug of the patient objectively; this is taken with or immediately after a meal and does not cause gastrointestinal side effects that are caused due to metformin. Dosages are scheduled individually according to requirements, as determined by healthcare providers, regarding the effectiveness of controlled glycemic and minimal probability of side effects.
Side Effects
Like other, drugs, Viglip-M 50/1000mg might also have some side effects not observed in everybody. You may experience the following common side effects:
- Gastrointestinal disturbances: including
nausea, vomiting, diarrhea, abdominal discomfort, and a lack of appetite, shows
up with metformin therapy. Most often, these symptoms go away with the
adaptation of the body toward the drug or when taken with food.
- Hypoglycemia: Vildagliptin, when used with sulfonylurea or
insulin in the treatment of diabetes, may predispose patients to hypoglycemia,
manifesting as abnormally low levels of blood sugar. Patients need to be
educated on the signs of this condition, and explicit counseling should be
given as to what is to be done when such symptoms appear.
- Renal Function Metformin: is associated with an adverse effect on renal function, more in those suffering from diseases of the kidneys or those taking drugs causing impairment in its proper functioning. Regular estimation of the renal function by the approximations in serum creatinine and eGFR should be warranted for the avertment of this complication.
Precautions
Patients must inform the physician whether he or she has the medical condition, allergy, or medication at present or taken from the past before starting therapy with Viglip-M 50/1000mg. Special Precautions/Contraindications The following are:
- Renal Impairment with Metformin: Metformin should be stopped
in severe renal failure with eGFR <30 mL/min/1.73 m2. Metformin may cause
lactic acidosis. Hemodialysis is required, and metformin should be withdrawn
with extreme caution in patients with mild-to-moderate renal failure.
- Hepatic Impairment: Dosing should be cautious in patients
with hepatic impairment, as vildagliptin is primarily an agent that is
distributed in the liver. Besides that, liver function tests should also be
measured regularly for any increase in liver enzymes.
- Pregnancy and Lactation: Viglip-M 50/1000 mg is not established to be safe in pregnancy and lactation and should be prescribed with caution in the case of a pregnant lady and a lactating mother, weighing benefits against risk.
Conclusion
That combination makes vildagliptin with metformin HCl in
Viglip-M a highly effective drug in the treatment of patients suffering from
type 2 diabetes mellitus. The combination of anti-hyperglycemic effectiveness
increases glycemic control and affects all defects of glucose metabolism,
thereby reducing the level of complications that arise from the disease.
The dosages that are prescribed have to be adhered to, glucose needs to be monitored on a day-to-day basis, and any untoward symptoms reported immediately to their clinician. Correctly managed and supplemented with proper lifestyle modification, Viglip-M goes a long way in promoting long-term health and betterment in the quality of life of patients suffering from type 2 diabetes.
Please book an appointment with the Best Diabetologist in Lahore, Karachi, Islamabad, and all major cities of Pakistan through InstaCare, or call our helpline at 03100002273 to find a verified doctor for your disease.
