Digestine is a medication that contains metoclopramide resinate, Metoclopramide resinate is a form of metoclopramide that is combined with a resin to form a sustained-release tablet. This means that the medication is released slowly over time, which can help to provide long lasting relief from symptoms.


Digestine Tablet Uses

Digestine tablet, which contains metoclopramide resinate, is primarily used to treat gastrointestinal symptoms such as:


  • Nausea and vomiting: It can be used to manage nausea and vomiting caused by various conditions such as migraine, chemotherapy, radiation therapy, and surgery.
  • Gastroparesis: This medication can help to increase the contractions of the upper digestive tract, which can aid in the emptying of the stomach in people with gastroparesis.
  • Indigestion: Digestine can provide relief from indigestion by increasing the muscle contractions in the digestive tract, which helps to move food through the stomach and intestines more efficiently.
  • Reflux: It may also be used to manage symptoms of gastroesophageal reflux disease (GERD) by increasing the pressure of the lower esophageal sphincter, which can help prevent the backflow of stomach acid into the esophagus.

Drug Interactions

Some of usual drug interactions of Digestine are:

  • Anticholinergic drugs: These drugs can counteract the effects of Digestine and reduce its effectiveness. Examples of anticholinergic drugs include atropine, benztropine, and diphenhydramine.
  • Central nervous system depressants: These medications can increase the sedative effects of Digestine, leading to excessive drowsiness or even respiratory depression. Examples of central nervous system depressants include opioids, tranquilizers, and sedatives.
  • Dopamine antagonists: These drugs can increase the risk of side effects such as extrapyramidal symptoms, which can cause tremors, rigidity, or abnormal movements. Examples of dopamine antagonists include haloperidol, risperidone, and metoclopramide.
  • Serotonin modulators: These medications can interact with Digestine and increase the risk of serotonin syndrome, which can cause symptoms such as confusion, agitation, and seizures. Samples of serotonin modulators incorporate selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants.

Disease Interactions

Some of the disease interactions of Digestine are:

  • Gastrointestinal obstruction: Digestine should not be used in people with gastrointestinal obstruction because it can worsen the obstruction and lead to serious complications.
  • Parkinson's disease: Digestine should be used with caution in people with Parkinson's disease because it can worsen the symptoms of the disease and cause extrapyramidal symptoms.
  • Seizure disorders: Digestine can lower the seizure threshold and increase the risk of seizures, especially in people with a history of seizure disorders.
  • Liver or kidney disease: Digestine should be used with caution in people with liver or kidney disease because it can increase the risk of side effects and reduce the clearance of the medication from the body.
  • Hypertension: Digestine can increase blood pressure and should be used with caution in people with hypertension.

Food Interactions

There are no known food interactions with Digestine, which contains metoclopramide resinate. However, some types of food can affect the absorption and effectiveness of the medication. For example, high-fat meals can delay the absorption of Digestine, while acidic foods and beverages can increase the absorption and concentration of the medication in the body. It is recommended to take Digestine on an empty stomach, at least 30 minutes before meals, to optimize its absorption and effectiveness.


View More: Ansaid - Uses Side Effects And Price In Pakistan


Side Effects of Digestine Tablet

Some usual side effects of Digestine include:

  • Drowsiness
  • Fatigue
  • Dizziness
  • Restlessness
  • Headache
  • Diarrhea
  • Nausea
  • Dry mouth
  • Increased urination
  • Abdominal pain

In rare cases, Digestine can cause more complicated side effects such as:

  • Extrapyramidal symptoms (EPS) including dystonia, akathisia, and linguofacial dyskinesia
  • Neuroleptic malignant syndrome (NMS)
  • Seizures
  • Depression
  • Anxiety
  • Confusion
  • Hallucinations

Dosage Forms of Digestine Tablet

Digestine which contains metoclopramide resinate is available in different dosage forms, including:

  • Tablets: Digestine tablets are available in different strengths, including 5 mg, 10 mg, and 20 mg. They are usually taken orally, with or without food, according to the dosage instructions provided by the healthcare provider.
  • Syrup: Digestine syrup is available in different strengths, including 1 mg/mL and 5 mg/mL. It is usually taken orally, with or without food, according to the dosage instructions provided by the healthcare provider.
  • Injection: Digestine injection is available in different strengths, including 5 mg/mL and 10 mg/mL. It is commonly given by a healthcare provider in a hospital or clinic spot.

Dosing Information

The following general dosing information for Digestine:

  • For nausea and vomiting: The usual adult dose of Digestine is 10 mg to 20 mg, taken orally up to four times a day before meals and at bedtime. The highest regular dose is 60 mg. The usual dose for children is 0.1 mg/kg to 0.15 mg/kg, taken orally up to four times a day before meals and at bedtime.
  • For gastroesophageal reflux disease (GERD): The usual adult dose of Digestine is 10 mg to 15 mg, taken orally up to four times a day before meals and at bedtime. The highest regular dose is 60 mg. The usual dose for children is 0.1 mg/kg to 0.15 mg/kg, taken orally up to four times a day before meals and at bedtime.
  • For diabetic gastroparesis: The usual adult dose of Digestine is 10 mg to 20 mg, taken orally up to four times a day before meals and at bedtime. The highest regular dose is 60 mg.

For other gastrointestinal disorders: The usual adult dose of Digestine is 10 mg to 20 mg, taken orally up to four times a day before meals and at bedtime. The highest regular dose is 60 mg.


Storage of Digestine Tablet

Store Digestine tablets and syrup at room temperature (between 20°C to 25°C) in a dry place, away from direct sunlight, heat, and moisture. Do not store them in the bathroom or near the kitchen sink.


Packaging of Digestine Tablet

Tablets: Digestine tablets are usually packaged in blister packs containing 10 or 20 tablets. The blister packs are then packaged in cardboard boxes with the necessary information such as the dosage, expiry date, and batch number.


Digestine Tablet Price In Pakistan

Digestine Tablet Price In Pakistan is Rs. 289 per pack.


You can easily buy online medicine In Pakistan and get it delivered to your doorstep with InstaCare. Visit the website or call at 03171777509 for further information.


Source: https://instacare.pk/blog/digestine-tablet-uses-side-effects-and-price-in-pakistan