Introduction

Onset is a medication that contains the active ingredient ondansetron. Ondansetron is a type of medication called a selective serotonin receptor antagonist, which effort by choke the work of serotonin in the body.


Uses of onset tablet 

Onset can be used for the following purposes:

  • Chemotherapy-induced nausea and vomiting: onset can help prevent and treat nausea and vomiting caused by chemotherapy.
  • Radiation therapy-induced nausea and vomiting: onset may be used to prevent and treat nausea and vomiting caused by radiation therapy.
  • Post-operative nausea and vomiting: onset can be used to prevent and treat nausea and vomiting after surgery.
  • Gastroenteritis-induced nausea and vomiting
  • Morning sickness: onset can also be used to treat nausea and vomiting during pregnancy.

Drug interactions

Some examples of drugs that may interact with onset include:

  • Apomorphine: concurrent use of onset and apomorphine may cause low blood pressure and loss of consciousness.
  • Tramadol: onset may reduce the effectiveness of tramadol.
  • Carbamazepine: onset may increase the levels of carbamazepine in the blood, which can lead to adverse effects.
  • Rifampin: onset may decrease the effectiveness of rifampin.
  • Phenobarbital: onset may reduce the effectiveness of phenobarbital.
  • Serotonin reuptake inhibitors (ssris): concurrent use of onset and ssris may increase the risk of serotonin syndrome, which is a potentially life-threatening condition characterized by fever, agitation, confusion, and muscle rigidity.

Disease interactions

Some examples of medical conditions that may interact with onset include:

  • Liver disease: onset is primarily metabolized by the liver, and its clearance may be impaired in patients with liver disease. A lower dose of onset may be required in patients with liver disease.
  • Congenital long qt syndrome: onset may increase the risk of arrhythmias in patients with congenital long qt syndrome.
  • Intestinal obstruction: onset may mask the symptoms of intestinal obstruction, which can lead to delayed diagnosis and treatment.
  • Electrolyte imbalances: onset may cause electrolyte imbalances, such as hypokalemia and hypomagnesemia, which can worsen certain medical conditions.
  • Hypersensitivity: onset should be used with caution in patients with a history of hypersensitivity to ondansetron or other selective serotonin receptor antagonists.

Food interactions

Alcohol consumption may worsen the side effects of onset, such as dizziness and drowsiness. It is recommended to avoid alcohol while taking onset or to limit alcohol intake.


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Side effects of onset tablet

Some common side effects of onset include:

  • Headache
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Fatigue
  • Flushing
  • Fever
  • Muscle spasms

In rare cases, onset may cause more serious side effects, such as:

  • Allergic reactions, including anaphylaxis
  • Qt prolongation (a heart rhythm disorder)
  • Serotonin syndrome (a potentially life-threatening condition characterized by fever, agitation, confusion, and muscle rigidity)

Dosage forms

Onset, contains ondansetron, is available in various dosage forms,

  • Tablets: onset tablets are available in strengths of 4 mg and 8 mg. They are typically taken orally, with or without food, as directed by the healthcare provider.
  • Orally disintegrating tablets (odt): onset odts are available in strengths of 4 mg and 8 mg. They are designed to dissolve quickly in the mouth without the need for water.
  • Injection: onset injection is available in vials containing 2 mg/ml, 4 mg/ml, and 8 mg/4 ml of ondansetron. It is typically administered by healthcare professionals as an intravenous injection.
  • Oral solution: onset oral solution is available in a 4 mg/ml concentration

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Dosing information

The following dosing information is a general guideline:

  • For prevention of nausea and vomiting caused by chemotherapy: the recommended adult dose is 8 mg of onset taken orally 30 minutes before chemotherapy. This dose may be repeated every 8 hours for up to 2 days after chemotherapy. Alternatively, the healthcare provider may prescribe a single dose of 24 mg of onset orally.
  • For prevention of nausea and vomiting caused by radiation therapy: the recommended adult dose is 8 mg of onset taken orally 1 to 2 hours before radiation therapy. This dose may be repeated every 8 hours for 1 to 2 days after radiation therapy.
  • For prevention of postoperative nausea and vomiting: the recommended adult dose is 16 mg of onset taken orally 1 hour before anesthesia induction. This dose may be repeated every 8 hours for up to 24 hours after surgery.
  • For treatment of nausea and vomiting: the recommended adult dose is 8 mg of onset taken orally every 8 hours as needed. Alternatively, the healthcare provider may prescribe a single dose of 16 mg of onset orally.
  • For pediatric patients: the dosing information for pediatric patients may vary depending on the patient's age and weight.

Packaging

Some examples of the packaging of onset,

  • Tablets: onset tablets are typically packaged in blister packs or bottles. The blister packs may contain 10 or 30 tablets, while the bottles may contain 30 or 100 tablets.
  • Orally disintegrating tablets (odt): onset odts are typically packaged in blister packs or bottles. The blister packs may contain 10 or 30 tablets, while the bottles may contain 30 or 100 tablets.
  • Injection: onset injection is typically packaged in vials containing 2 mg/ml, 4 mg/ml, and 8 mg/4 ml of ondansetron. The vials may be packaged individually or in multi-dose vials.
  • Oral solution: onset oral solution is typically packaged in bottles containing 50 ml or 100 ml of solution.

Storage

General guidelines for storing onset:

  • Tablets and orally disintegrating tablets (odt): onset tablets and odts should be stored at room temperature, between 20°c to 25°c (68°f to 77°f), in a dry place. Avoid revealing them to wetness, heat, or straight sunlight.
  • Injection: onset injection should be stored at room temperature, between 20°c to 25°c (68°f to 77°f), in a dry place. Do not freeze the injection, and protect it from light.
  • Oral solution: onset oral solution should be stored at room temperature, between 20°c to 25°c (68°f to 77°f), in a dry place. It should be protected from light and kept in the original container.

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Source: https://instacare.pk/blog/onset-tablet-uses-side-effects-and-price-in-pakistan