Introduction
Onset is a medication that contains the active ingredient ondansetron. Ondansetron is a type of medication called a selective serotonin receptor antagonist, which effort by choke the work of serotonin in the body.
Uses of onset tablet
Onset can be
used for the following purposes:
- Chemotherapy-induced
nausea and vomiting: onset can help prevent and treat nausea and vomiting
caused by chemotherapy.
- Radiation
therapy-induced nausea and vomiting: onset may be used to prevent and treat
nausea and vomiting caused by radiation therapy.
- Post-operative
nausea and vomiting: onset can be used to prevent and treat nausea and vomiting
after surgery.
- Gastroenteritis-induced
nausea and vomiting
- Morning
sickness: onset can also be used to treat nausea and vomiting during pregnancy.
Drug interactions
Some
examples of drugs that may interact with onset include:
- Apomorphine:
concurrent use of onset and apomorphine may cause low blood pressure and loss
of consciousness.
- Tramadol:
onset may reduce the effectiveness of tramadol.
- Carbamazepine:
onset may increase the levels of carbamazepine in the blood, which can lead to
adverse effects.
- Rifampin:
onset may decrease the effectiveness of rifampin.
- Phenobarbital:
onset may reduce the effectiveness of phenobarbital.
- Serotonin reuptake
inhibitors (ssris): concurrent use of onset and ssris may increase the risk of
serotonin syndrome, which is a potentially life-threatening condition
characterized by fever, agitation, confusion, and muscle rigidity.
Disease interactions
Some examples
of medical conditions that may interact with onset include:
- Liver
disease: onset is primarily metabolized by the liver, and its clearance may be
impaired in patients with liver disease. A lower dose of onset may be required
in patients with liver disease.
- Congenital
long qt syndrome: onset may increase the risk of arrhythmias in patients with
congenital long qt syndrome.
- Intestinal
obstruction: onset may mask the symptoms of intestinal obstruction, which can
lead to delayed diagnosis and treatment.
- Electrolyte
imbalances: onset may cause electrolyte imbalances, such as hypokalemia and
hypomagnesemia, which can worsen certain medical conditions.
- Hypersensitivity:
onset should be used with caution in patients with a history of
hypersensitivity to ondansetron or other selective serotonin receptor
antagonists.
Food interactions
Alcohol consumption may worsen the side effects of onset, such as dizziness and drowsiness. It is recommended to avoid alcohol while taking onset or to limit alcohol intake.
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Side effects of onset tablet
Some common
side effects of onset include:
- Headache
- Constipation
- Diarrhea
- Dizziness
- Drowsiness
- Fatigue
- Flushing
- Fever
- Muscle
spasms
In rare
cases, onset may cause more serious side effects, such as:
- Allergic
reactions, including anaphylaxis
- Qt
prolongation (a heart rhythm disorder)
- Serotonin
syndrome (a potentially life-threatening condition characterized by fever,
agitation, confusion, and muscle rigidity)
Dosage forms
Onset,
contains ondansetron, is available in various dosage forms,
- Tablets:
onset tablets are available in strengths of 4 mg and 8 mg. They are typically
taken orally, with or without food, as directed by the healthcare provider.
- Orally
disintegrating tablets (odt): onset odts are available in strengths of 4 mg and
8 mg. They are designed to dissolve quickly in the mouth without the need for
water.
- Injection:
onset injection is available in vials containing 2 mg/ml, 4 mg/ml, and 8 mg/4
ml of ondansetron. It is typically administered by healthcare professionals as
an intravenous injection.
- Oral
solution: onset oral solution is available in a 4 mg/ml concentration
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Dosing
information
The
following dosing information is a general guideline:
- For
prevention of nausea and vomiting caused by chemotherapy: the recommended adult
dose is 8 mg of onset taken orally 30 minutes before chemotherapy. This dose
may be repeated every 8 hours for up to 2 days after chemotherapy.
Alternatively, the healthcare provider may prescribe a single dose of 24 mg of
onset orally.
- For prevention
of nausea and vomiting caused by radiation therapy: the recommended adult dose
is 8 mg of onset taken orally 1 to 2 hours before radiation therapy. This dose
may be repeated every 8 hours for 1 to 2 days after radiation therapy.
- For
prevention of postoperative nausea and vomiting: the recommended adult dose is
16 mg of onset taken orally 1 hour before anesthesia induction. This dose may
be repeated every 8 hours for up to 24 hours after surgery.
- For
treatment of nausea and vomiting: the recommended adult dose is 8 mg of onset
taken orally every 8 hours as needed. Alternatively, the healthcare provider
may prescribe a single dose of 16 mg of onset orally.
- For
pediatric patients: the dosing information for pediatric patients may vary
depending on the patient's age and weight.
Packaging
Some
examples of the packaging of onset,
- Tablets:
onset tablets are typically packaged in blister packs or bottles. The blister
packs may contain 10 or 30 tablets, while the bottles may contain 30 or 100
tablets.
- Orally
disintegrating tablets (odt): onset odts are typically packaged in blister
packs or bottles. The blister packs may contain 10 or 30 tablets, while the
bottles may contain 30 or 100 tablets.
- Injection:
onset injection is typically packaged in vials containing 2 mg/ml, 4 mg/ml, and
8 mg/4 ml of ondansetron. The vials may be packaged individually or in
multi-dose vials.
- Oral
solution: onset oral solution is typically packaged in bottles containing 50 ml
or 100 ml of solution.
Storage
General
guidelines for storing onset:
- Tablets and
orally disintegrating tablets (odt): onset tablets and odts should be stored at
room temperature, between 20°c to 25°c (68°f to 77°f), in a dry place. Avoid
revealing them to wetness, heat, or straight sunlight.
- Injection:
onset injection should be stored at room temperature, between 20°c to 25°c
(68°f to 77°f), in a dry place. Do not freeze the injection, and protect it
from light.
- Oral solution: onset oral solution should be stored at room temperature, between 20°c to 25°c (68°f to 77°f), in a dry place. It should be protected from light and kept in the original container.
You can easily buy online medicine In Pakistan and get it delivered to your doorstep with InstaCare. Visit the website or call at 03171777509 for further information.
Source: https://instacare.pk/blog/onset-tablet-uses-side-effects-and-price-in-pakistan