Only your healthcare provider or someone who is authorized to do so should provide venofer® (iron sucrose injection, usp), which is approved for the treatment of iron deficiency anemia (ida) in adults and children (2 years of age and older) who have chronic kidney disease (ckd). It is unknown how much iron replacement therapy should be administered to children under the age of two who have peritoneal, hemodialysis-dependent, or non-dialysis-dependent chronic kidney disease.

If you have a known iron sucrose allergy, you should not take venofer. Any medical problems, drugs, and supplements you are taking should be disclosed to your healthcare professional.


Uses of venofar injection

Indicated for the treatment of chronic renal disease patients' iron deficient anemia is venofer (ckd). Only continuous infusion or gradual injection is permitted when using venofer. Venofer's dosage is specified in mg of elemental iron.

  • An intravenous (iv) type of iron called venofer® (iron sucrose) injection, usp is a necessary component for producing new red blood cells.
  • Additionally, iron is required for your bone marrow to produce healthy new red blood cells and produce hemoglobin, which transports oxygen to your organs and tissues.
  • Your blood test, which shows how many red blood cells you have as well as whether your blood cells have adequate iron, is the basis for the decision to give venofer to you or your child.
  • Increasing your iron levels can help you have more hemoglobin if you have an iron deficiency.
  • Taking care of your anemia could help you stay healthy in the future.
  • Treated ida can eventually result in cardiac problems, and if you already have them, it can exacerbate them.

Side effects of venofer injection

Diarrhea, upset stomach, vomiting, headache, dizziness, hypotension, pruritus (itching), pain in extremity, arthralgia (joint pain), back pain, muscular cramps, injection site responses, chest pain, and regional edema are the most frequent adverse effects in adult patients (2%). (swelling).


Headache, viral respiratory tract infection, peritonitis, upset stomach, vomiting, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension, and hypertension are the side effects that occur most frequently (>2%) in pediatric patients (increased blood pressure).


Not all possible side effects are listed here; if you have any questions, speak with your healthcare professional.

Discoloration at the injection site may have occurred. If the injection site irritates you, let your doctor know.


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How venofer is working

By reviewing your blood tests, your doctor will be able to determine how venofer is performing. Along with your hemoglobin and red blood cell count, your doctor will likely monitor the following two tests:

Ferritin. This protein has iron that has been kept in reserve.

Saturation of transferrin (tsat). In order to produce healthy red blood cells, transferrin transports iron from the storage protein (ferritin) or the iron you are receiving for treatment to the bone marrow.


Warnings

Patients on venofer have experienced severe hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting, and/or other allergy symptoms), some of which have been deadly and life threatening. Venofer may significantly lower blood pressure (decreased blood pressure). After each dose, your doctor will keep a tight eye on you for 30 minutes.


If you have any adverse reaction symptoms, including but not limited to rash, chest pain, cough, dizziness, passing out, shortness of breath, sweating, or tightness in your throat, call your healthcare provider or seek emergency medical attention right away.


Iron overload is a condition that can be dangerous if venofer is used in excess.


Periodic blood tests are required for all patients receiving venofer to track the level of iron in the blood. The absorption of oral iron solutions may be decreased by venofer.


Notify your healthcare provider if you are expecting a child, plan to get pregnant, or are already nursing a baby. Untreated ida in pregnancy may have hazards for both the mother and the fetus.


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Dosage form and strength

Injection: single-dose vials of 50 mg/2.5 ml, 100 mg/5 ml, or 200 mg/10 ml (20 mg/ml). (3)

Dosage of venofer:

Only intravenous infusion or gradual injection is permitted when using venofer. Venofer's dosage is specified in mg of elemental iron. There are 20 mg of elemental iron per ml.

Administration mode

Only intravenously, with a gradual injection or infusion, should venofer be administered. Venofer's dosage is specified in mg of elemental iron. There are 20 mg of elemental iron per ml.

Adult patients with chronic kidney disease requiring hemodialysis (hdd-ckd)

Per each hemodialysis session, administer 100 mg of venofer undiluted as a gradual intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in no more than 100 ml of 0.9% nacl over a period of at least 15 minutes [see how supplied/storage and handling (16.2)]. Early in the dialysis session, give venofer (generally within the first hour). The typical venofer treatment plan consists of 1000 mg. If iron shortage reappears, venofer treatment might be repeated.

Adult patients with chronic kidney disease not requiring dialysis (ndd-ckd)

Children with hdd-ckd (2 years of age and older) undergoing iron maintenance therapy

Venofer should be taken for iron maintenance treatment at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, given every two weeks for 12 weeks by slow intravenous injection over 5 minutes, or diluted in 0.9% nacl at a concentration of 1 to 2 mg/ml and given over 5 to 60 minutes.

Supplied/storage and handling [16.2] for further information.) Do not dilute to concentrations lower than 1 mg/ml.) If required, venofer treatment can be repeated.


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