Septran is one of the most commonly used mixtures of antibiotics in the form of 80 mg of sulfamethoxazole and 400 mg of trimethoprim. It has been prescribed very frequently to the patients with a great many bacterial infections and is very often remembered for use in the conditions related to UTIs, respiratory infections, and gastrointestinal infections.
This shows how Septran serves as a synthetize for folic acid
in bacteria hence, applied well for numerous germs and pathogens. So here on
this article we will present for you about usage, its side effect dosage, Price
and all relevant questions or answers on the subject about Septran.
Action
Through synergistic actions of these two active ingredients constituting, Septran exercises action against bacteria
- Sulfamethoxazole: This is a sulfonamide that inhibits
bacterial synthesis of folate by competing with PABA. It needs PABA, which
inhibits the synthesis of folic acid that in turn causes deficiency and hence
affects multiplication and growth.
- Trimethoprim: This is an antibiotic that is a dihydrofolate
reductase inhibitor. This inhibits the enzyme which converts dihydrofolate to
tetrahydrofolate. This in turn inhibits the production of folate, hence acting
as a complete antagonist to sulfamethoxazole.
- Thus, inhibiting at two steps of the pathway of folate synthesis, Septran acts as a very effective controller of bacterial growth and stops infection from going on.
Uses of Septran
Septran is prescribed in the treatment of a wide range of
infections that come from bacteria such as,
1. Respiratory Tract Infections
Septran is used to treat a wide range of respiratory infections such as
- Bronchitis: This is inflammation of the bronchial tubes
hence coughing, and trouble in breathing.
- Pneumonia: It is an infection that causes inflammation of either both air sacs in a lung or just one or more of them and also filling them with fluid or pus.
2. UTIs
Most of the use for Septran, though is to treat UTI which
the bacteria make their existence known in its presence with signs like dysuria
and urinal frequency and urgency. It acts on pathogens like Escherichia coli,
etc which are responsible for the above disease.
3. Intestinal Infections
The drug can be used in some infections of the
gastrointestinal tract. This infection will be relieved by diarrhea with the
bacterial pathogen; especially it occurs as a result of the infection caused by
sensitive bacteria.
4. Ear Infections
Otitis media is another one of those infections that
involves the use of Septran, even in children most of the time. It is called a
middle ear infection.
5. Skin Infections
Septran is used in skin invasions including cellulites, and
abscesses resulting from a breakout of bacteria usually characterized by
inflammation.
6. Pneumocystis Pneumonia (PCP)
In the Immune compromised customers like HIV/AIDS same as in
the Prophylactic line Septran is used in the treatment line drug to prevent one
from getting Pneumocystis pneumonia which is an opportunity infection of a
severe type.
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Dosage and Administration
- Relative dosing of Septran that depends on the type of
infection and level of seriousness and also the patient's own characteristics.
This is only the general prescription dosing but can be applied on issuing the
prescription;
- Adult Dosage: 1 tablet containing 80 mg/400 mg which should
be administered orally two times a day depending on the period between 5 to 14
days relating the nature and severity level of the infection.
- For Children: Dosage in children is usually weight dependent, and dosing should be done according to what a pediatrician tells you.
How to Take
- Hydration: The doses of Septran are consumed with full
glasses of water, so that the side effects like crystal Luria-crystals in
urine, by the intake of sulfonamides may be less.
- Drug Course: The course of drugs should be strictly completed by the patients so that they are symptom-free so that there will not be a single reason for the drugs to get resistance.
Side Effects
Though Septran is very well tolerated by most of the
patients, some patients are not free from its side effects. Some of the common
and significant side effects are as follows:
Common Side Effects
- Gastrointestinal side effects: Nausea, vomiting, diarrhea,
and anorexia are very common.
- Cutaneous effects: Hypersensitivity and previous history
with drugs containing sulfa moieties results in pruritus, rash, and
photosensitivity.
- Headaches and dizziness are common with high doses
Major Side Effects
The next side effects are very infrequent but severe and require immediate medical intervention:
- Other Aggressive skin conditions: rash
characterized by blistering or peeling of the skin as a spreading rash caused
by other fatal diseases such as Stevens-Johnson syndrome or toxic epidermal
necrolysis.
- Reactions. Inflammation in the face lips or even throat
accompanied with difficulty in breathing is known as an allergic reaction known
as anaphylactic and has to be dealt with by a qualified person.
- Hematological Effects: Septran may, on rare instances cause
blood disorders like thrombocytopenia reduced platelets or leukopenia reduced
white blood cells that may lead to an increase in bleeding tendency or
infection.
- Liver and Kidney Effects: Hepatitis or raised levels of liver enzymes might be confirmed, and renal function should be monitored in the patients who have known pre-existing renal diseases.
Contraindications and Precautions
There are patient groups that should not receive Septran or must be administered with extreme caution:
- Allergic reactions: All the patients who have known
hypersensitivity reactions to sulfonamides or trimethoprim are absolutely
contraindicated to Septran.
- Kidney dysfunction: Dosage must be adjusted if the patient
has poor function of his kidneys.
- Liver disease: Patient suffering from failure should take
Septran with extreme caution in high observation with medical care
- Pregnancy and breastfeeding: Pregnancy and lactation mothers should seek advice from a physician prior to the use of Septran since this medication needs to be avoided during pregnancy, especially first trimester
Cost of Septran
Much has been said about trying to calculate the price
range, which in turn is dependent on the purchasing place and the chemist's
shop, the patient being insured then again dependent on Septran 80 mg/400 mg.
Thus one always has to dial the local chemist or one may refer to the website of the product also that gives one an idea of how much cost it involves;
additionally, one has to request for the generic so it is cheaper since it's
believed.
Conclusion
The Septran 80mg/400mg tablets combine a mighty force of antibiotic drugs for easy eradication of bacteria causing infection. Since the synthesis occurs at the stage of folic acid in bacteria, a whole spectrum of the bacterial pathogenic actions takes place, and as with any antibiotic, usage of Septran requires careful and responsible utilization and involves known side effects and contraindications, thereby requiring advice in each case through a healthcare professional.
Being bactericidal, the action of an agent
does lie within that process. It allows them to fully participate in the
treatment through knowing how the drug is used, side effects, and proper use of
Septran, hence excellent health results.
