leucovorin inj 50 mg 1 vialx5 ml

Highlights

• Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer.
• Leucovorin injection is used to treat people who have accidentally received an overdose of methotrexate or similar medications.

Description

Leucovorin inj 50mg 1 vialx5 ml

• Leucovorin is in a class of medications called folic acid analogs.
• It works by protecting healthy cells from the effects of methotrexate or similar medications while allowing methotrexate to enter and kill cancer cells.

Directions For Use

• Leucovorin is administered at 200 mg/m2 by slow intravenous injection over a minimum of 3 minutes, followed by 5-fluorouracil at 370 mg/m2 by intravenous injection. 2. Leucovorin is administered at 20 mg/m2 by intravenous injection followed by 5-fluorouracil at 425 mg/m2 by intravenous injection.

Warnings

• Leucovorin (leucovorin calcium) should be given to a pregnant woman only if clearly needed.
• Caution should be exercised when leucovorin (leucovorin calcium) is administered to a nursing mother.

Precautions

• Parenteral administration is preferable to oral dosing if there is a possibility that the patient may vomit and not absorb the leucovorin (leucovorin calcium) .
• Leucovorin (leucovorin calcium) has no effect on non-hematologic toxicities of methotrexate such as the nephrotoxicity resulting from drug and/or metabolite precipitation in the kidney.
• Since leucovorin (leucovorin calcium) enhances the toxicity of fluorouracil leucovorin (leucovorin calcium) /5-fluorouracil combination therapy for advanced colorectal cancer should be administered under the supervision of a physician experienced in the use of antimetabolite cancer chemotherapy.
• Particular care should be taken in the treatment of elderly or debilitated colorectal cancer patients as these patients may be at increased risk of severe toxicity.