HLA B27 Allele by PCR Test Price and Details
7 labs availableKnown As: HLA-B27 Antigen,Human Leukocyte Antigen B27
Last Updated On Tuesday, April 29, 2025
What is Hla-B27-Allele-By-Pcr?
A blood test called HLA-B27 looks for a protein on the surface of white blood cells. Its scientific name is human leukocyte antigen B27 (HLA-B27).
HLAs are proteins that assist the immune system of the body in distinguishing between its cells and external, dangerous things. They are produced using instructions provided by inherited genes.
Human leukocyte antigen B27 (HLA-B27) is a particular protein that can be seen on cell surfaces. This phrase is also used to describe the gene that produces the HLA-B27 protein. So, it is claimed that this test will reveal if the HLA-B27 protein is present on the surface of white blood cells or not. The HLA are proteins that aid the immune system in recognizing and distinguishing between "self" and "non-self" cells in the body. Yet, the HLA B27 class 1 allele has been connected to the development of autoimmune conditions such as juvenile rheumatoid arthritis, ankylosing spondylitis, and others.
More than 90% of individuals with ankylosing spondylitis have been shown to carry the HLA-B27 allele, yet only 1% of these individuals go on to develop the disease. As a result, it is well known to have significant diagnostic significance. An allele-specific PCR (polymerase chain reaction; a process that quickly creates millions to billions of copies of the specific DNA sample and amplifies it to make it easier for the scientist to examine) approach is utilized for HLA-B27 allele detection.
How the Test is Administered?
Needed is a sample of blood. Most frequently, a vein on the inside of the elbow or the back of the hand is used to take blood.
How to Get Ready for the Exam?
To get ready for the test, no additional measures are
required.
The Experience of the Test
You may experience some discomfort during the blood draw procedure, or you may merely experience a prickling or stinging sensation. There can be some throbbing afterward.
What do Unusual Findings Indicate?
A positive test indicates the presence of HLA-B27. It implies a higher-than-average risk of having or developing a few autoimmune illnesses. When the immune system unintentionally targets and obliterates healthy body tissue, a disease known as an autoimmune illness develops.
- Spondylarthritis, a type of arthritis, can be diagnosed by
your doctor with the use of a positive test result. The following conditions
are classified as this type of arthritis:
- Spondylitis with ankylosing
- Crohn's disease- or ulcerative colitis-related arthritis
- Arthritis psoriatic (arthritis associated with psoriasis)
- Inflammatory arthritis
- Sacroiliitis (inflammation of the sacroiliac joint)
(inflammation of the sacroiliac joint)
- Uveitis
A positive HLA-B27 test could aid with the diagnosis of spondylarthritis if you have symptoms or physical evidence of the condition. Yet, HLA-B27 is present in some healthy individuals and does not always indicate that you have a disease.
Is There Any Risk Associated with Hla-B27-Allele-By-Pcr?
- Blood draw risks are minimal, although they could include:
- A lot of blood
- Fainting or experiencing dizziness
- Hematoma (blood accumulating under the skin) (blood
accumulating under the skin)
- Infection (a minor possibility any time the skin is broken)
(a slight risk any time the skin is broken)
Frequently Asked Questions
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